On Two Issues of Molecular Network Models in Systems Biology – A Review

Two points are definitely different between network models in systems biology and those in engineering fields. One is that most network models (structures) in biology are not static but change depending on external conditions, and the other is that the models including unmeasured variables frequently emerged so as to measure the variables under the conditions with as less perturbation to the organism as possible. To consider the two points specific to systems biology, we have designed two methods by statistical and symbolic-computation approaches, respectively. Here, we will describe the methods with their merits and pitfalls.